HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

New rearrangement pattern after treatment of hairy-cell leukemia with 2-chlorodeoxyadenosine.

Abstract
Leukemic hairy cells are clonally proliferating B-lymphoid cells with clonal rearrangements of genes for immunoglobulin chains. We describe a patient with a new hairy-cell clone after treatment with 2-chlorodeoxyadenosine (2-CdA). In this patient, a single course of 2-CdA resulted in good partial remission of hairy-cell leukemia, but Southern blot analysis of bone marrow biopsies and polymerase chain reaction using seminested amplifications with consensus primers revealed a new rearranged band 4 months after therapy with 2-CdA. Four years after therapy, the patient is in complete clinical remission and both bands disappeared during follow-up. The new rearranged band might have been related to prior treatment of hairy-cell leukemia with 2-CdA.
AuthorsM Schirmer, M Haun, K Grünewald, F Geisen, W Hilbe, J Thaler, G Konwalinka
JournalActa haematologica (Acta Haematol) Vol. 103 Issue 2 Pg. 109-11 ( 2000) ISSN: 0001-5792 [Print] Switzerland
PMID10838455 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2000 S. Karger AG, Basel
Chemical References
  • Antimetabolites, Antineoplastic
  • Cladribine
Topics
  • Antimetabolites, Antineoplastic (therapeutic use)
  • B-Lymphocytes (pathology)
  • Blotting, Southern
  • Cladribine (therapeutic use)
  • Clone Cells (pathology)
  • Gene Rearrangement, B-Lymphocyte
  • Genes, Immunoglobulin
  • Humans
  • Leukemia, Hairy Cell (drug therapy, genetics, pathology)
  • Male
  • Middle Aged
  • Neoplasm, Residual
  • Neoplastic Stem Cells (pathology)
  • Remission Induction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: