Abstract |
Leukemic hairy cells are clonally proliferating B-lymphoid cells with clonal rearrangements of genes for immunoglobulin chains. We describe a patient with a new hairy-cell clone after treatment with 2-chlorodeoxyadenosine (2-CdA). In this patient, a single course of 2-CdA resulted in good partial remission of hairy-cell leukemia, but Southern blot analysis of bone marrow biopsies and polymerase chain reaction using seminested amplifications with consensus primers revealed a new rearranged band 4 months after therapy with 2-CdA. Four years after therapy, the patient is in complete clinical remission and both bands disappeared during follow-up. The new rearranged band might have been related to prior treatment of hairy-cell leukemia with 2-CdA.
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Authors | M Schirmer, M Haun, K Grünewald, F Geisen, W Hilbe, J Thaler, G Konwalinka |
Journal | Acta haematologica
(Acta Haematol)
Vol. 103
Issue 2
Pg. 109-11
( 2000)
ISSN: 0001-5792 [Print] Switzerland |
PMID | 10838455
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2000 S. Karger AG, Basel |
Chemical References |
- Antimetabolites, Antineoplastic
- Cladribine
|
Topics |
- Antimetabolites, Antineoplastic
(therapeutic use)
- B-Lymphocytes
(pathology)
- Blotting, Southern
- Cladribine
(therapeutic use)
- Clone Cells
(pathology)
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Leukemia, Hairy Cell
(drug therapy, genetics, pathology)
- Male
- Middle Aged
- Neoplasm, Residual
- Neoplastic Stem Cells
(pathology)
- Remission Induction
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