Auto-antibodies to the asialoglycoprotein receptor in sera of children with auto-immune hepatitis.

Abstract

UNLABELLED:

Most studies on the prevalence of asialoglycoprotein antibodies have involved adults. In this study the prevalence of antibodies to the human asialoglycoprotein receptor (ASGP-R) was determined in 63 children with auto-immune hepatitis. It was shown that 75% of those with auto-immune hepatitis type 1 and 40% of those with auto-immune hepatitis type 2 were positive and the presence of anti-ASGP-R auto-antibodies, at a mean titre of 1:1,600 and 1:1,000 respectively. No statistical significance was found between anti-ASGP-R positive and negative patients with respect to the median age at onset, proportion of females and ALT levels. However, the titre of anti-ASGP-R antibodies correlated significantly with hypergammaglobulinaemia.

CONCLUSION:

Anti-asialoglycoprotein receptor antibodies are frequently present in the sera of children with auto-immune hepatitis, particularly type 1, The presence of these antibodies is an indirect marker of inflammatory activity.

• Authors: O Hajoui, D Debray, S Martin, F Alvarez
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 159 Issue 5 Pg. 310-3 (May 2000) ISSN: 0340-6199 [Print] Germany
• PMID: 10834513 (Publication Type: Journal Article)

Chemical References

• Asialoglycoprotein Receptor
• Asialoglycoproteins
• Autoantibodies
• Receptors, Cell Surface
• gamma-Globulins

Topics

• Adolescent
• Asialoglycoprotein Receptor
• Asialoglycoproteins (immunology)
• Autoantibodies (blood)
• Autoimmune Diseases (blood, immunology)
• Child
• Child, Preschool
• Female
• Hepatitis (blood, immunology)
• Humans
• Male
• Receptors, Cell Surface (immunology)
• gamma-Globulins (analysis)