Abstract | BACKGROUND: OBJECTIVE: METHODS: A total of 351 patients were enrolled into this 4-week, double-blind, double-dummy, randomized, parallel group study. Patients received either TAA aqueous nasal spray (220 microg) or loratadine (10 mg) once daily. Efficacy variables were rhinitis symptom changes from baseline, physician global evaluations, and the patient dropout rate due to insufficient treatment effect. Safety and quality of life also was evaluated. RESULTS: Both TAA aqueous-treated and loratadine-treated patients had improvement in symptoms as early as day 1. Overall, TAA aqueous was significantly (P < .05) more effective than loratadine in reducing total nasal symptoms and individual symptoms of nasal congestion, nasal itch, and sneezing. Ocular symptoms improved from baseline in both groups. There was no statistically significant difference between groups based on physician global evaluation. A similar number of patients in each group discontinued the study due to ineffective treatment. Triamcinolone acetonide aqueous patients maintained a significantly (P < .05) better quality of life in three of the dimensions (activity, nasal symptoms, and practical problems) and for overall quality of life. There were no differences between the two treatment groups in the incidence of adverse events, none of which were clinically significant. CONCLUSIONS:
|
Authors | J Condemi, R Schulz, J Lim |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 84
Issue 5
Pg. 533-8
(May 2000)
ISSN: 1081-1206 [Print] United States |
PMID | 10831008
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Allergic Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Loratadine
- Triamcinolone Acetonide
|
Topics |
- Administration, Intranasal
- Adolescent
- Adult
- Aged
- Anti-Allergic Agents
(pharmacokinetics, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacokinetics, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Loratadine
(pharmacokinetics, therapeutic use)
- Male
- Middle Aged
- Quality of Life
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Therapeutic Equivalency
- Triamcinolone Acetonide
(administration & dosage, pharmacokinetics, therapeutic use)
|