Although the mechanism of susceptibility to
chronic persistent hepatitis B virus (HBV)
infection is not well clarified, immunogenetic factors of the host may have a role. Recently, a strong association between
HLA-DR13 and the self-limited course of HBV
infection has been reported. To determine whether the elimination of HBV is related to a particular HLA allele, we studied the HBV markers and
HLA-DR phenotypes of 1,272 Koreans who had visited Yonsei University Medical Center for
renal transplantation. They included 330 renal transplant donors. Subjects were categorized into 3 different groups: the "Unexposed Group" (UE; n = 946) with negative HBV markers, the "Chronic Carrier Group" (CC; n = 83), who were
hepatitis B surface antigen (
HBsAg)-positive, and the "Spontaneously Cleared Group" (SC; n = 243), who were
HBsAg-negative with
antibodies to
HBsAg (anti-HBs) and
hepatitis B core antigen (anti-HBc).
HLA-DR4 was the most common type in all groups.
HLA-DR6 was significantly more frequent in 69 of 243 subjects with SC (28. 4%) than in 8 of 83 subjects with CC (9.6%) (P <.001; relative risk [RR] = 3.72).
HLA-DR9 was significantly more frequent in CC than in SC (P <.001; RR = 0.33).
HLA-DR13 showed a stronger association with the clearance of HBV than the other
HLA-DR6 subgroup. The distribution of
HLA-DR phenotypes was similar regardless of renal disease. Our data indicate that
HLA-DR6, especially
HLA-DR13, is one of the host factors, which influences the immune response to HBV, and may be associated with self-elimination of HBV in Koreans.