Abstract | BACKGROUND: METHODS: RESULTS: All hemoglobin solutions produced vasoconstriction, manifested by elevated mean systemic and pulmonary artery pressures without a significant decrease in cardiac index compared with the sham group. Resuscitation with maltose-containing solutions elevated arterial and regional PCO2 and depressed arterial pH and gastric pHi (p < 0.05 for all). Splanchnic and renal blood flows were reduced in the low P50 + 8% maltose group (p < 0.05 vs. sham and baseline for renal blood flow), possibly indicating greater regional vasoconstriction in this group. Ileal mucosal damage was more severe in the maltose-containing groups and correlated with decreased pHi. CONCLUSION:
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Authors | S C Glasgow, A S Shah, R B Noone Jr, M R Gottfried, S R Eachempati, T L Talarico, S N Vaslef |
Journal | The Journal of trauma
(J Trauma)
Vol. 48
Issue 5
Pg. 884-92; discussion 892-3
(May 2000)
ISSN: 0022-5282 [Print] United States |
PMID | 10823532
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Hemoglobins
- Solutions
- pyridoxalated-hemoglobin-polyethylene glycol conjugate
- Polyethylene Glycols
- Maltose
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Topics |
- Acidosis, Respiratory
(chemically induced)
- Animals
- Blood Gas Analysis
- Blood Pressure
(drug effects)
- Chemistry, Pharmaceutical
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Female
- Fluid Therapy
(methods)
- Hemoglobins
(chemistry, therapeutic use)
- Hydrogen-Ion Concentration
- Maltose
(chemistry, therapeutic use)
- Polyethylene Glycols
(chemistry, therapeutic use)
- Random Allocation
- Regional Blood Flow
(drug effects)
- Resuscitation
(methods)
- Shock, Hemorrhagic
(metabolism, physiopathology, therapy)
- Solutions
- Swine
- Vasoconstriction
(drug effects)
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