[Effect of melatonin and epithalamin on activity of marker enzymes in the cell membrane in the forebrain of rats under acute hypoxia].

Abstract

The effects of a single-shot intraperitoneally administration of melatonin in a dose of 1 mg per kg body weight and epithalamin in a dose of 2.5 mg per kg body weight on the activities of Na+, K(+)-ATPase and 5'-nucleotidase were investigated in the forebrain of juvenile male white rats under the acute hypobaric hypoxia. The melatonin and epithalamin administration against the background of acute hypoxia prevented an acute hypoxia inducing decrease in the activity of Na+, K(+)-ATPase as well as increased in the activity of 5'-nucleotidase. Such effects of pineal hormones can promote antihypoxic protection of neurons.

• Authors: I I Zamors'kyĭ, V P Pishak, I F Meshchyshen
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 1999 Nov-Dec Vol. 71 Issue 6 Pg. 33-6 Ukraine
• Vernacular Title: Vplyv melatoninu ta epitalaminu na aktyvnist' markernykh fermentiv plazmatychnykh membran klityn peredn'oho mozku shchuriv za umov hostroï hipoksiï.
• PMID: 10820844 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Peptides
• epithalamin
• 5'-Nucleotidase
• Sodium-Potassium-Exchanging ATPase
• Melatonin

Topics

• 5'-Nucleotidase (metabolism)
• Animals
• Biomarkers
• Cell Membrane (drug effects, enzymology)
• Hypoxia (enzymology)
• Male
• Melatonin (pharmacology)
• Peptides (pharmacology)
• Prosencephalon (cytology, drug effects)
• Rats
• Sodium-Potassium-Exchanging ATPase (metabolism)