Anticarcinogenicity potential of spinasterol isolated from squash flowers.

Abstract

Spinasterol, an antimutagen, was isolated from squash flowers by solvent partitioning and repeated vacuum liquid chromatography. Spinasterol was then tested for its anticarcinogenic potential by using the mouse skin tumor assay. There was a 90% skin tumor incidence for the positive control group (DMBA + croton oil + acetone). At a concentration of 15.0 microg/0.2 ml acetone, spinasterol decreased the incidence of skin tumors by 55.6% and decreased the number of tumors by 65.0% when applied immediately after croton oil. Hence, spinasterol showed antitumorigenic potential. It is not a co-carcinogen nor a co-tumor promoter as there was no increase in the incidence of skin tumors after spinasterol application. Teratogenesis Carcinog. Mutagen. 20:99-105, 2000.

• Authors: I M Villaseñor, A P Domingo
• Journal: Teratogenesis, carcinogenesis, and mutagenesis (Teratog Carcinog Mutagen) Vol. 20 Issue 3 Pg. 99-105 ( 2000) ISSN: 0270-3211 [Print] United States
• PMID: 10820420 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 Wiley-Liss, Inc.

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Solvents
• spinasterol
• 9,10-Dimethyl-1,2-benzanthracene
• Chloroform
• Croton Oil
• Stigmasterol
• Methanol

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Animals
• Anticarcinogenic Agents (isolation & purification, pharmacology)
• Carcinogens (toxicity)
• Chloroform
• Chromatography, Liquid
• Cocarcinogenesis
• Croton Oil (toxicity)
• Cucurbitaceae (chemistry)
• Drug Screening Assays, Antitumor
• Methanol
• Mice
• Molecular Structure
• Skin Neoplasms (chemically induced, prevention & control)
• Solvents
• Stigmasterol (analogs & derivatives, isolation & purification, pharmacology)
• Time Factors