[Radiosensitization of human tumor HeLa cells induced by methyl ester of 6-oxo-6-[2,2-ethylenedioxy-5-(dimethoxycarbonylmethyl)-cyclope nt- 1-yL]-hexanoic acid].

Abstract

Methyl ester of 6-oxo-6-[2,2-ethylenedioxy-5-(dimethoxycarbonylmethyl)- cyclopent-1-yl]-hexanoic acid (7-keto-9,9-ethylenedioxiprostanoid, that is analogue of 11-deoxy-PGE1 with modified chains) at concentration 10(-6) mol/l displayed maximal (25%) sensitizing effect when was tested in a range of concentrations 10(-7)-10(-5) mol/l and HeLa cells were gamma-irradiated at dose of 2 Gy, that was compared with metronidazol action. Optimal time of prostanoid contact with cells was between 30 and 60 min, and metronidazol--60 min. Prostanoid effect was exhibited at irradiation doses from 2 to 4 Gy and reached maximum of 46% at 4 Gy, its DMF was 1.5 as well as that of metronidazol. Cytotoxicity of comparable compounds was approximately equal. By its chemical structure and sensitizing features this 7-keto-9,9-ethylenedioxiprostanoid is a prototype of new radiosensitizing drug.

• Authors: I G Dad'kov, B B Kuz'mitskiĭ, I P Antonevich, F A Lakhvich
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 2000 Mar-Apr Vol. 40 Issue 2 Pg. 204-7 ISSN: 0869-8031 [Print] Russia (Federation)
• Vernacular Title: Radiosensibilizatsiia kletok HeLa opukholi cheloveka pod vliianiem metilovogo éfira 6-okso-6-[2,2-étilendioksi-5-(dimetoksikarbonilmetil)- tsiklopent-1-il]-geksanovoĭ kisloty.
• PMID: 10819046 (Publication Type: Journal Article)

Chemical References

• 7-keto-9,9-ethylenedioxiprostanoid
• Radiation-Sensitizing Agents
• Alprostadil
• 11-deoxyprostaglandin E1

Topics

• Alprostadil (analogs & derivatives, chemistry, pharmacology)
• HeLa Cells (drug effects, radiation effects)
• Humans
• Radiation Tolerance (drug effects)
• Radiation-Sensitizing Agents (chemistry, pharmacology)
• Radiotherapy