Abstract | BACKGROUND: METHOD: In a naturalistic setting, by reviewing medical records, we assessed response to quetiapine and factors associated with response to quetiapine in 145 consecutive patients newly treated with the drug at a nonprofit academic psychiatric hospital. These patients had received a discharge diagnosis of bipolar disorder (manic, mixed, or depressive type), major depression with psychotic features, schizophrenia, schizoaffective disorder (bipolar or depressive type), delusional disorder, or psychosis not otherwise specified (NOS) according to DSM-IV criteria. RESULTS: Patients with a diagnosis of bipolar disorder, manic, mixed, or depressed and schizoaffective disorder, bipolar type displayed higher response rates (> 74%) compared with patients with schizophrenia. However, this finding did not achieve statistical significance. A diagnosis of major depression with psychotic features (p = .02) and longer duration of illness (p = .03) were associated with less chance of responding. CONCLUSION:
|
Authors | C A Zarate Jr, A Rothschild, K E Fletcher, A Madrid, J Zapatel |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 61
Issue 3
Pg. 185-9
(Mar 2000)
ISSN: 0160-6689 [Print] United States |
PMID | 10817103
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Quetiapine Fumarate
|
Topics |
- Adult
- Affective Disorders, Psychotic
(diagnosis, drug therapy, psychology)
- Antipsychotic Agents
(therapeutic use)
- Bipolar Disorder
(drug therapy, psychology)
- Chronic Disease
- Depressive Disorder
(drug therapy, psychology)
- Dibenzothiazepines
(therapeutic use)
- Female
- Hospital Records
- Humans
- Male
- Prognosis
- Psychotic Disorders
(drug therapy, psychology)
- Quetiapine Fumarate
- Retrospective Studies
- Schizophrenia
(drug therapy)
- Schizophrenia, Paranoid
(drug therapy, psychology)
- Schizophrenic Psychology
- Severity of Illness Index
- Treatment Outcome
|