Abstract |
To examine the effects of 2,5-hexanedione (HD) on the glucose metabolism in the spinal cord, glucose utilization rate ( GUR) and distribution volume of glucose (DV) were measured in the white matter and anterior horn of the spinal cord in 8 rats exposed to HD for 4 weeks and in 10 control rats. The GUR and DV were determined by the quantitative microdetermination method using non-tracer 2-deoxyglucose based on the three-compartments model of Sokoloff. GURs in the white matter and anterior horn and DV in the anterior horn in the HD-exposed rats were significantly lower than those in the control rats. In the multiple regression analysis, GUR in the white matter of HD-exposed rats was significantly related to blood HD concentration. It is suggested that the decrease of GUR in the white matter is a major effect of HD in the spinal cord.
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Authors | K Yokoyama, S Araki, A Akabayashi, T Kato, T Sakai, H Sato |
Journal | Industrial health
(Ind Health)
Vol. 38
Issue 2
Pg. 189-94
(Apr 2000)
ISSN: 0019-8366 [Print] Japan |
PMID | 10812841
(Publication Type: Journal Article)
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Chemical References |
- Hexanones
- Neurotoxins
- 2,5-hexanedione
- Glucose
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Topics |
- Administration, Oral
- Animals
- Glucose
(metabolism)
- Hexanones
(pharmacology, poisoning)
- Male
- Neurotoxins
(pharmacology, poisoning)
- Poisoning
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Spinal Cord
(physiology)
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