Abstract | BACKGROUND: OBJECTIVE: To compare the effects of MA oral suspension (O.S.), 800 mg/day, versus placebo on weight in geriatric nursing home patients with weight loss or low body weight. DESIGN: Twelve-week, randomized, double-blind, placebo-controlled trial with a 13-week follow-up period. SETTING: PATIENTS: INTERVENTIONS: Patients were randomly assigned to receive placebo or MA 800 mg/day for 12 weeks and were then followed for 13 weeks off treatment. MEASUREMENTS: Primary outcome was measured by weight and appetite change. Secondary outcome measures included sense of well-being, enjoyment of life, change in depression scale, laboratory nutrition parameters, energy intake counts, body composition, and adverse events. RESULTS: At 12 weeks there were no significant differences in weight gain between treatment groups, whereas MA-treated patients reported significantly greater improvement in appetite, enjoyment of life, and well-being. Body composition was not statistically different between the two groups. At Week 25 (3 months after treatment), 61.9% of MA-treated patients had gained > or =1.82 kg (4 lbs) compared to 21.7% of placebo patients. CONCLUSIONS: In geriatric patients with weight loss or low body weight MA improves appetite and well-being after 12 weeks of treatment. During the 3 months of MA treatment, there was no statistically significant weight gain (> or =4 lbs). Three months after treatment, weight gain (> or =4 lbs) was significantly increased in MA-treated patients.
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Authors | S S Yeh, S Y Wu, T P Lee, J S Olson, M R Stevens, T Dixon, R J Porcelli, M W Schuster |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 48
Issue 5
Pg. 485-92
(May 2000)
ISSN: 0002-8614 [Print] United States |
PMID | 10811540
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Appetite
(drug effects)
- Body Composition
- Body Weight
(drug effects)
- Cachexia
(drug therapy)
- Double-Blind Method
- Female
- Homes for the Aged
- Humans
- Male
- Megestrol Acetate
(administration & dosage, therapeutic use)
- Middle Aged
- New York
- Nutritional Status
- Quality of Life
- Weight Loss
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