Inhibitory effect of Apernyl on production of bradykininlike substance in pulp.

Abstract

In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykininlike substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or anti-in-flammatory effect of Apernyl is a result of its inhibiting bradykinin production.

• Authors: T Kudo, M Kawagoe, T Hayashi, J Takezawa, R Inoki
• Journal: Journal of dental research (J Dent Res) 1975 Sep-Oct Vol. 54 Issue 5 Pg. 1082-6 ISSN: 0022-0345 [Print] United States
• PMID: 1081101 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drug Combinations
• Parabens
• Formaldehyde
• Aspirin
• Bradykinin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Aspirin (pharmacology)
• Biological Assay
• Bradykinin (analysis, metabolism)
• Dental Pulp (drug effects, metabolism)
• Dental Pulp Exposure
• Depression, Chemical
• Dogs
• Drug Combinations
• Electric Stimulation
• Formaldehyde (adverse effects)
• Male
• Parabens (pharmacology)
• Pulpitis (chemically induced, metabolism)
• Rats