Abstract |
A single oral administration of phenoxy herbicides, viz. 2,4-dichlorophenoxyacetic acid (2,4-D), amino salt, sodium salt, diethylene glycol, iso-octyl and octyl ethers in a dose of LD16, was found to produce a pronounced suppressive effect on humoral immunity on day 5. The 2,4-D derivatives under study, administered in the same dose, stimulated the manifestations of delayed-type hypersensitivity in mice immunized with sheep red blood cells. The effect of the inhibition of antibody formation to thymus-dependent antigen ranged in the order of the increase in the toxicity of substances: amino salt, diethylene glycol ether, 2,4-D, sodium salt, iso-octyl and octyl ethers. On the contrary, the intensity of delayed-type hypersensitivity was more pronounced with regard to substances having greater toxicity.
|
Authors | E A Imel'baeva, S N Teplova, F Kh Kamilov |
Journal | Zhurnal mikrobiologii, epidemiologii i immunobiologii
(Zh Mikrobiol Epidemiol Immunobiol)
2000 Mar-Apr
Issue 2
Pg. 60-3
ISSN: 0372-9311 [Print] Russia (Federation) |
Vernacular Title | Otsenka vliianiia proizvodnykh 2,4-dikhlorfenoksiuksusnoĭ kisloty na gumoral'noe i kletochnoe zveno immuniteta. |
PMID | 10808577
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
Chemical References |
- Herbicides
- 2,4-Dichlorophenoxyacetic Acid
|
Topics |
- 2,4-Dichlorophenoxyacetic Acid
(analogs & derivatives, pharmacology)
- Animals
- Antibody Formation
(drug effects)
- Herbicides
(pharmacology)
- Hypersensitivity, Delayed
(etiology, immunology)
- Immunity, Cellular
(drug effects)
- Immunization
(methods)
- Male
- Mice
|