Th2-dependent airway eosinophilia is regulated by preproenkephalin.

Abstract

We have used preproenkephalin (PPNK)-deficient mice to study the role of PPNK in the development of airway inflammation. Airway eosinophilia was established by either sensitization followed by airway challenge with OVA or by infection with Nippostrongylus brasiliensis. Both models induce a strong Th2 immune response, characterized by an IL-5-dependent airway eosinophilia. We observed that although the accumulation of lymphocytes in the airways of PPNK-deficient mice was similar to that induced in control mice, IL-5 production and eosinophil infiltration were reduced. We conclude from this work that PPNK has a role in enhancing Th2 cell function and that this molecule may be an important target in asthma immunotherapy.

• Authors: S Hook, M Prout, M Camberis, M Konig, A Zimmer, G Van Heeke, G Le Gros
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 107 Issue 1 Pg. 59-65 (Jul 10 2000) ISSN: 0165-5728 [Print] Netherlands
• PMID: 10808051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Enkephalins
• Protein Precursors
• preproenkephalin

Topics

• Animals
• Antibody Formation
• Cytokines (biosynthesis)
• Enkephalins (deficiency, genetics, physiology)
• Eosinophilia (immunology, pathology, physiopathology)
• Lung Diseases (immunology, pathology, physiopathology)
• Mice
• Mice, Inbred C57BL (genetics)
• Protein Precursors (deficiency, genetics, physiology)
• Th2 Cells (immunology, metabolism, physiology)