Abstract | BACKGROUND: Different authors have postulated both toxic and protective effects for nitric oxide (NO) in the pathophysiology of active inflammation. AIM: To examine the role of NO, especially that produced by the inducible form of nitric oxide synthase (iNOS), by investigating the effects of NOS inhibitors and NO donors on inflammation in experimental acute colitis. METHODS: RESULTS AND CONCLUSIONS: Inhibition of NO production by either L-NAME or AG worsened DSS-induced inflammation, suggesting a protective role for NO in acute colitis. On the other hand, a NO donor also exaggerated DSS-induced inflammatory parameters, suggesting that acute colitis may be aggravated by either too much or too little NO. These results suggest that medical treatment of ulcerative colitis must aim for maintenance of appropriate NO levels in the intestinal mucosa.
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Authors | Y Yoshida, A Iwai, K Itoh, M Tanaka, S Kato, R Hokari, T Miyahara, H Koyama, S Miura, M Kobayashi |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 14 Suppl 1
Pg. 26-32
(Apr 2000)
ISSN: 0269-2813 [Print] England |
PMID | 10807400
(Publication Type: Journal Article)
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Chemical References |
- Guanidines
- Nitric Oxide
- Dextran Sulfate
- Nitric Oxide Synthase
- pimagedine
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Colitis, Ulcerative
(chemically induced, metabolism)
- Dextran Sulfate
(administration & dosage, adverse effects)
- Enzyme Induction
- Guanidines
(metabolism)
- Male
- NG-Nitroarginine Methyl Ester
(metabolism)
- Nitric Oxide
(physiology)
- Nitric Oxide Synthase
(metabolism)
- Rats
- Rats, Sprague-Dawley
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