Abstract | BACKGROUND: In a previous study, subantimicrobial dose doxycycline (SDD) significantly improved clinical parameters associated with periodontal health in patients with adult periodontitis (AP) when used as an adjunct to a maintenance schedule of supragingival scaling and dental prophylaxis. In this double-blind, placebo-controlled, parallel-group, multicenter study, the efficacy and safety of SDD were evaluated in conjunction with scaling and root planing (SRP) in patients with AP. METHODS: Patients (n = 190) received SRP at the baseline visit and were randomized to receive either SDD 20 mg bid or placebo bid for 9 months. Efficacy parameters included the per-patient mean changes in clinical attachment level (CAL) and probing depth (PD) from baseline, the per-patient percentages of tooth sites with attachment loss (AL) > or = 2 mm and > or = 3 mm from baseline, and the per-patient percentage of tooth sites with bleeding on probing. Prior to analysis, tooth sites were stratified by the degree of disease severity evident at baseline RESULTS: In tooth sites with mild to moderate disease and severe disease (n = 183, intent-to-treat population), improvements in CAL and PD were significantly greater with adjunctive SDD than with adjunctive placebo at 3, 6, and 9 months (all P <0.05). In tooth sites with severe disease, the per-patient percentage of sites with AL > or = 2 mm from baseline to month 9 was significantly lower with adjunctive SDD than with adjunctive placebo (P<0.05). Improvements in clinical outcomes occurred without detrimental shifts in the normal periodontal flora or the acquisition of doxycycline resistance or multiantibiotic resistance. SDD was well tolerated, with a low incidence of discontinuations due to adverse events. CONCLUSIONS: The adjunctive use of SDD with SRP is more effective than SRP alone and may represent a new approach in the long-term management of AP.
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Authors | J G Caton, S G Ciancio, T M Blieden, M Bradshaw, R J Crout, A F Hefti, J M Massaro, A M Polson, J Thomas, C Walker |
Journal | Journal of periodontology
(J Periodontol)
Vol. 71
Issue 4
Pg. 521-32
(Apr 2000)
ISSN: 0022-3492 [Print] United States |
PMID | 10807113
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Placebos
- Doxycycline
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage, adverse effects, therapeutic use)
- Bacteria
(drug effects)
- Dental Plaque
(microbiology)
- Dental Prophylaxis
- Dental Scaling
- Double-Blind Method
- Doxycycline
(administration & dosage, adverse effects, therapeutic use)
- Female
- Gingival Hemorrhage
(classification, drug therapy, prevention & control)
- Humans
- Male
- Middle Aged
- Periodontal Attachment Loss
(classification, drug therapy, prevention & control)
- Periodontal Pocket
(classification, drug therapy, prevention & control)
- Periodontitis
(classification, drug therapy, prevention & control)
- Placebos
- Root Planing
- Safety
- Statistics as Topic
- Tetracycline Resistance
- Treatment Outcome
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