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A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

Abstract
Using the characteristic morphological changes of mammalian cells, we screened novel antimitotic substances and found that a strain of Streptomyces sp. No.9885 produced FR182877. This substance was isolated from the culture broth by ethyl acetate extraction, silica gel column chromatography and ODS column chromatography. Structural studies on FR182877 suggested that it had a unique hexacyclic structure encompassing its highly strained double bond. FR182877 exhibited potent antitumor activities against murine ascitic tumor and solid tumor in vivo.
AuthorsB Sato, H Muramatsu, M Miyauchi, Y Hori, S Takase, M Hino, S Hashimoto, H Terano
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 53 Issue 2 Pg. 123-30 (Feb 2000) ISSN: 0021-8820 [Print] England
PMID10805571 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • FR 182877
  • Polycyclic Compounds
Topics
  • Animals
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Line
  • Cricetinae
  • Drug Screening Assays, Antitumor
  • Female
  • Fermentation
  • Humans
  • Inhibitory Concentration 50
  • Kidney (cytology, drug effects)
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred Strains
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Neoplasms, Experimental (drug therapy)
  • Polycyclic Compounds (chemistry, isolation & purification, pharmacology)
  • Streptomyces (chemistry, classification, metabolism)
  • Toxicity Tests
  • Tumor Cells, Cultured

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