Diagnosis of disseminated intravascular coagulation by hemostatic molecular markers.

Abstract

In the present study, the positive rate of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC), soluble fibrin monomer (sFM), and D-dimer for the diagnosis of disseminated intravascular coagulation (DIC) was evaluated. The study comprised 307 patients with DIC, 123 with pre-DIC, and 121 with non-DIC. Plasma levels of TAT, PPIC, sFM, and D-dimer were significantly higher in DIC and pre-DIC patients than in non-DIC patients. In DIC patients, the positive rate of sFM was high and that of D-dimer was low; the positive rate of PPIC was higher in patients with hematopoietic malignancy than in those without this disease. In pre-DIC patients, the positive rate of all markers was low (<0.16), and the positive rate of PPIC was relatively high. In non-DIC patients, the positive rate of all hemostatic markers was low (<0.16), that of sFM being the lowest. Scoring the positive rate of TAT, PPIC, and sFM disclosed the following results: 72% of DIC patients had three or more points, 17.6% of pre-DIC patients had three or more points, and almost all (96.6%) non-DIC patients had two or less points. Scoring the positive rate of TAT, PPIC, and D-dimer disclosed the following results: 52.9% of DIC patients and 27.4% of pre-DIC patients had three or more points and almost all (96.7%) non-DIC patients had 2 or less points. These data suggest that the combination of TAT, PPIC, and sFM is useful for making the diagnosis of DIC.

• Authors: H Wada, E Gabazza, T Nakasaki, M Shimura, K Hiyoyama, K Deguchi, M Nishikawa, N Sakuragawa, H Shiku
• Journal: Seminars in thrombosis and hemostasis (Semin Thromb Hemost) Vol. 26 Issue 1 Pg. 17-21 ( 2000) ISSN: 0094-6176 [Print] United States
• PMID: 10805276 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifibrinolytic Agents
• Biomarkers
• Fibrin Fibrinogen Degradation Products
• alpha-2-Antiplasmin
• antithrombin III-protease complex
• fibrin fragment D
• fibrinmonomer
• plasmin-plasmin inhibitor complex
• Antithrombin III
• Peptide Hydrolases
• Fibrinolysin

Topics

• Antifibrinolytic Agents (analysis)
• Antithrombin III (analysis)
• Biomarkers
• Disseminated Intravascular Coagulation (blood, diagnosis)
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinolysin (analysis)
• Humans
• Partial Thromboplastin Time
• Peptide Hydrolases (analysis)
• Thrombophilia (blood, diagnosis)
• alpha-2-Antiplasmin