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[Vitamin B 6 metabolism in phenylketonuria].

Abstract
Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml should be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.
AuthorsL A Kharitonchik, V M Kodentsova, O A Vrzhesinskaia, S N Denisova, V B Spirichev
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 2000 Jan-Feb Vol. 46 Issue 1 Pg. 81-8 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleOsobennosti obmena vitamina B-6 pri fenilketonurii.
PMID10802890 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Pyridoxic Acid
  • Pyridoxal Phosphate
  • Pyridoxine
  • Riboflavin
Topics
  • Child
  • Female
  • Humans
  • Male
  • Phenylketonurias (metabolism)
  • Pyridoxal Phosphate (blood)
  • Pyridoxic Acid (urine)
  • Pyridoxine (metabolism)
  • Riboflavin (metabolism)

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