Abstract |
Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml should be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.
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Authors | L A Kharitonchik, V M Kodentsova, O A Vrzhesinskaia, S N Denisova, V B Spirichev |
Journal | Voprosy meditsinskoi khimii
(Vopr Med Khim)
2000 Jan-Feb
Vol. 46
Issue 1
Pg. 81-8
ISSN: 0042-8809 [Print] Russia (Federation) |
Vernacular Title | Osobennosti obmena vitamina B-6 pri fenilketonurii. |
PMID | 10802890
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Pyridoxic Acid
- Pyridoxal Phosphate
- Pyridoxine
- Riboflavin
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Topics |
- Child
- Female
- Humans
- Male
- Phenylketonurias
(metabolism)
- Pyridoxal Phosphate
(blood)
- Pyridoxic Acid
(urine)
- Pyridoxine
(metabolism)
- Riboflavin
(metabolism)
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