Clinicopathological and biological assessment of lung cancers with pleural dissemination.

Abstract

BACKGROUND:

This study provides the surgical outcome of lung cancer patients with pleural dissemination, with the assessment of the clinicopathological and biological prognostic factors.

METHODS:

Forty-three patients who underwent operations were studied. Vascular endothelial growth factor (VEGF) and autocrine motility factor receptor (AMFR/gp78) expression was immunohistochemically evaluated.

RESULTS:

In total, the overall 3 and 5-year survival rates were 31.4% and 13.1%, respectively. The patients who underwent the pleuropneumonectomy had a worse outcome than those who underwent limited operations (pleurectomy plus parenchymal resections were less than pneumonectomy). VEGF and AMFR/gp78 were highly expressed in primary tumors. Among the patients who underwent limited operations, pathological types other than adenocarcinoma and high expression of VEGF were significantly associated with a worse outcome. The pathological type was the only characteristic to retain a significant independent prognostic impact on overall survival.

CONCLUSIONS:

The results imply the validation of limited operation for lung cancer with pleural dissemination for the local control. High frequency of VEGF and AMFR/gp78 expression conform to the interpretation that patients with pleural dissemination have a high-risk of systemic disease.

• Authors: Y Ohta, Y Tanaka, T Hara, M Oda, S Watanabe, J Shimizu, Y Watanabe
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 69 Issue 4 Pg. 1025-9 (Apr 2000) ISSN: 0003-4975 [Print] Netherlands
• PMID: 10800788 (Publication Type: Journal Article)

Chemical References

• Endothelial Growth Factors
• Lymphokines
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors
• Glucose-6-Phosphate Isomerase

Topics

• Adenocarcinoma (pathology)
• Adult
• Aged
• Carcinoma, Squamous Cell (pathology)
• Endothelial Growth Factors (metabolism)
• Female
• Glucose-6-Phosphate Isomerase (metabolism)
• Humans
• Immunohistochemistry
• Lung Neoplasms (pathology)
• Lymphokines (metabolism)
• Male
• Middle Aged
• Pleura (pathology)
• Prognosis
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors