Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.

Abstract

To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

• Authors: Y Iwase, Y Takemura, M Ju-ichi, C Ito, H Furukawa, S Kawaii, M Yano, X Y Mou, J Takayasu, H Tokuda, H Nishino
• Journal: Cancer letters (Cancer Lett) Vol. 154 Issue 1 Pg. 101-5 (Jun 01 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10799745 (Publication Type: Journal Article)

Chemical References

• Antigens, Viral
• Epstein-Barr virus early antigen
• Flavonoids
• Plant Extracts
• 3,3',4',5,6,7,8-heptamethoxyflavone
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Antigens, Viral (metabolism)
• Female
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Mice
• Mice, Inbred ICR
• Papilloma (chemically induced, drug therapy, metabolism)
• Plant Extracts (chemistry, isolation & purification, pharmacology)
• Skin Neoplasms (chemically induced, drug therapy, metabolism)
• Tetradecanoylphorbol Acetate
• Time Factors
• Virus Activation (drug effects)