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Magnesium for preventing preterm birth after threatened preterm labour.

AbstractBACKGROUND:
Magnesium therapy is sometimes continued after an episode of threatened preterm labour in an attempt to prevent the onset of further preterm contractions.
OBJECTIVES:
The objective of this review was to assess the effects of magnesium maintenance therapy on preventing preterm birth after threatened preterm labour.
SEARCH STRATEGY:
We searched the Cochrane Pregnancy and Childbirth Group trials register.
SELECTION CRITERIA:
Randomised controlled trials of magnesium therapy given to women after threatened preterm labour.
DATA COLLECTION AND ANALYSIS:
Trial quality assessment and data extraction were done independently by two reviewers.
MAIN RESULTS:
Two trials were included. Both were of poor quality and neither study included any long-term follow up of infants. The incidence of preterm birth or perinatal mortality was not reduced by magnesium maintenance therapy compared to alternative therapy or no treatment.
REVIEWER'S CONCLUSIONS:
There is not enough evidence to show that magnesium maintenance therapy is effective in preventing preterm birth after an episode of threatened preterm labour.
AuthorsC A Crowther, V Moore
JournalThe Cochrane database of systematic reviews (Cochrane Database Syst Rev) Issue 2 Pg. CD000940 ( 2000) ISSN: 1469-493X [Electronic] England
PMID10796222 (Publication Type: Journal Article, Review, Systematic Review)
Chemical References
  • Magnesium
Topics
  • Female
  • Humans
  • Magnesium (therapeutic use)
  • Obstetric Labor, Premature (drug therapy)
  • Pregnancy
  • Tocolysis

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