[Anesthesia for MIDCAB (minimally invasive direct coronary bypass) in a patient with Tangier disease: a case report].

Abstract

Tangier disease is a rare, autosomally-inherited disorder of lipoprotein metabolism characterized by absence or marked deficiency of normal high density lipoprotein (HDL) cholesterol in plasma resulting in the accumulation of cholesteryl esters in various organs. The patient was a 55-yr-old male diagnosed as Tangier disease 16 years before. He had angina on exercise and his coronary angiogram revealed triple vessel disease including left main trunk (LMT) lesion. Stenosis of the right coronary artery was treated by percutaneous transluminal coronary angioplasty (PTCA). He was scheduled for a MIDCAB for further PTCA to be performed to relieve the stenosis of LMT. Preoperative laboratory data and physical examination showed total cholesterol 36 mg.dl-1, HDL-cholesterol 2 mg.dl-1, apoprotein A-I not-detected, pancytopenia, hyperplastic orange tonsils, splenomegaly and hepatomegaly. Clonidine 0.225 mg was orally given as a preanesthetic medication. Anesthesia was induced with fentanyl and midazolam and maintained with propofol, sevoflurane and supplemental fentanyl. Nitroglycerin and diltiazem were infused continuously. ST segment was elevated transiently during the clamping of the left anterior descending branch. Hemodynamic parameters were stable during the operation. He was extubated 2 hours after the end of the operation. No significant changes were found in postoperative EKG, total cholesterol, HDL-cholesterol and triglyceride. Perioperative course was uneventful.

• Authors: M Ohnishi, A Hazama, T Kita, T Mammoto, T Akamatsu, N Kambara, T Sakai, Y Kishi
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 49 Issue 4 Pg. 407-9 (Apr 2000) ISSN: 0021-4892 [Print] Japan
• PMID: 10793527 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Anesthesia
• Angioplasty, Balloon, Coronary
• Coronary Artery Bypass
• Coronary Disease (etiology, therapy)
• Humans
• Male
• Middle Aged
• Minimally Invasive Surgical Procedures
• Tangier Disease (complications)