Abstract | BACKGROUND: In eukaryotic cells, nucleolar processing of preribosomal RNAs (prerRNAs) is assisted by a large number of small nucleolar RNAs (snoRNAs) that function in the 2'-O-methylation or the pseudouridylation of rRNAs. Most snoRNAs so far characterized are encoded and processed from introns of premRNAs. RESULTS: We found a novel intronic snoRNA gene, named U50HG, located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). The U50HG gene is composed of six exons, whose spliced transcripts have little potential for coding a protein, and its introns produce both U50 and U50-like (U50') snoRNAs that are localized in nucleoli. It possesses an oligopyrimidine tract that is characteristic of the 5'-terminal oligopyrimidine (5'TOP) class of genes which have been shown to be coordinately regulated in response to cell growth. CONCLUSIONS:
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Authors | R Tanaka, H Satoh, M Moriyama, K Satoh, Y Morishita, S Yoshida, T Watanabe, Y Nakamura, S Mori |
Journal | Genes to cells : devoted to molecular & cellular mechanisms
(Genes Cells)
Vol. 5
Issue 4
Pg. 277-87
(Apr 2000)
ISSN: 1356-9597 [Print] England |
PMID | 10792466
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Small Nucleolar
- Ribosomal Proteins
- Poly A
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Topics |
- Alternative Splicing
- Base Sequence
- Cell Nucleolus
(genetics, metabolism)
- Chromosome Breakage
- Chromosome Mapping
- Chromosomes, Human, Pair 3
(genetics)
- Chromosomes, Human, Pair 6
(genetics)
- Exons
- Genes
(genetics)
- HeLa Cells
- Humans
- Introns
(genetics)
- Lymphoma, B-Cell
(genetics, pathology)
- Molecular Sequence Data
- Poly A
(genetics)
- RNA, Small Nucleolar
(genetics)
- Ribosomal Proteins
(genetics)
- Sequence Homology, Nucleic Acid
- Transcription, Genetic
- Translocation, Genetic
- Tumor Cells, Cultured
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