Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel.

Abstract

Docetaxel (Taxotere), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.

• Authors: C Y Chu, C H Yang, C Y Yang, G H Hsiao, H C Chiu
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 142 Issue 4 Pg. 808-11 (Apr 2000) ISSN: 0007-0963 [Print] England
• PMID: 10792238 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Paclitaxel

Topics

• Adult
• Antineoplastic Agents, Phytogenic (adverse effects)
• Drug Eruptions (etiology)
• Erythema (chemically induced)
• Female
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Paclitaxel (administration & dosage, adverse effects)
• Paresthesia (chemically induced)