[A patient with advanced gastric cancer who obtained downstaging and underwent radical surgery by neoadjuvant chemotherapy].

Abstract

The patient was a 74-year-old man with extremely advanced gastric cancer. A CT scan of the abdomen showed enlargement of many huge abdominal para-aortic lymph nodes. Neoadjuvant chemotherapy (NAC) was planned in order to reduce or eliminate the tumor. Two cycles of FLP combination therapy (5-fluorouracil, leucovorin, cisplatin) were given. After NAC, a CT scan revealed marked shrinkage of the No. 16 lymph nodes, and a distal gastrectomy with extended radical lymph node dissection including the No. 16 nodes was performed. The histological effect was judged to be grade 2. There were no viable cancer cells in the No. 16 lymph nodes. The FLP combination therapy as NAC was so effective that it induced downstaging from stage IVb to IIIb.

• Authors: M Kawahara, A Nashimoto, H Yabusaki, Y Takii, Y Tsuchiya, O Tanaka, J Sasaki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 27 Issue 4 Pg. 609-12 (Apr 2000) ISSN: 0385-0684 [Print] Japan
• PMID: 10791005 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cisplatin
• Leucovorin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, pathology)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (therapeutic use)
• Fluorouracil (therapeutic use)
• Humans
• Leucovorin (therapeutic use)
• Lymph Nodes (diagnostic imaging)
• Male
• Neoplasm Staging
• Stomach Neoplasms (drug therapy, pathology)
• Tomography, X-Ray Computed