Abstract |
Docetaxel (TXT) has been shown to be an up-regulator of human pyrimidine nucleoside phosphorylase (PyNPase) in tumors. We have tried to use the combination of low-dose weekly TXT with 5'-DFUR (LD + D) in patients with advanced or metastatic breast cancer. In this study, we compared the clinical efficacy of LD + D with that of conventional full-dose TXT (FD) and that of low-dose weekly TXT (LD). Twenty-one patients received 3 or 4 cycles of FD 60 mg/m2 every 3 or 4 weeks (group I), 14 patients received 8 cycles of LD 20-30 mg/m2 every week (group II) and 25 patients received 8 cycles of LD 20-30 mg/m2 weekly with oral 5'-DFUR 600-1,200 mg per day (group III). The overall response rates of groups I, II and III were 29%, 29% and 52% (p = 0.24), respectively. Grade 3-4 neutropenia was observed in 91% of group I, 6% of group II and 3% of group III. Nausea was present in 27% of group I, 28% of group II and 40% of group III. Higher incidence of gastrointestinal symptoms was found in LD + D, but the symptoms abated when the doses of 5'-DFUR were reduced. Low-dose weekly TXT with oral 5'-DFUR produced a higher response rate, but less hematologic toxicity than full-dose TXT, suggesting that this combination therapy is clinically useful and may be effective for patients with advanced or metastatic breast cancer.
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Authors | Y Harada, N Ohuchi, K Ohnuki, G Amano, R Yoshida, A Furuta, H Ikegaki, G Kijima, S Satomi |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 27
Issue 4
Pg. 579-84
(Apr 2000)
ISSN: 0385-0684 [Print] Japan |
PMID | 10791000
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Taxoids
- Floxuridine
- Docetaxel
- Paclitaxel
- doxifluridine
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Topics |
- Antineoplastic Agents, Phytogenic
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Breast Neoplasms
(drug therapy)
- Docetaxel
- Drug Administration Schedule
- Floxuridine
(administration & dosage, adverse effects)
- Humans
- Middle Aged
- Neoplasm Metastasis
- Paclitaxel
(administration & dosage, adverse effects, analogs & derivatives)
- Pilot Projects
- Taxoids
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