Antibiotic beads in the treatment of diabetic pedal osteomyelitis.

Abstract

Antibiotic-impregnated polymethylmethacrylate (PMMA) beads have improved the outcome of osteomyelitis treatment in both experimental models and clinical trials. The primary benefit of antibiotic-impregnated PMMA beads is that they provide high local concentrations of antibiotic while systemic levels of antibiotic remain low. Little has been written about the specific use of antibiotic-impregnated PMMA beads in the treatment of diabetic pedal osteomyelitis. The authors review antibiotic-impregnated PMMA beads and provide examples of their use in the treatment of diabetic pedal osteomyelitis.

• Authors: B Roeder, C C Van Gils, S Maling
• Journal: The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons (J Foot Ankle Surg) 2000 Mar-Apr Vol. 39 Issue 2 Pg. 124-30 ISSN: 1067-2516 [Print] United States
• PMID: 10789104 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Biocompatible Materials
• Bone Cements
• Drug Carriers
• Vancomycin
• Polymethyl Methacrylate
• Tobramycin

Topics

• Absorbable Implants
• Aged
• Anti-Bacterial Agents (administration & dosage, adverse effects, pharmacology)
• Biocompatible Materials (chemistry)
• Bone Cements (chemistry)
• Debridement
• Diabetes Complications
• Diabetes Mellitus, Type 1 (complications)
• Drug Carriers
• Drug Delivery Systems
• Foot Diseases (drug therapy, surgery)
• Humans
• Male
• Middle Aged
• Osteomyelitis (drug therapy, surgery)
• Polymethyl Methacrylate (chemistry)
• Staphylococcal Infections (drug therapy)
• Tobramycin (administration & dosage)
• Treatment Outcome
• Vancomycin (administration & dosage)