Loratadine/pseudoephedrine for nasal symptoms in seasonal allergic rhinitis: a double-blind, placebo-controlled study.

Abstract	In this double-blind, placebo-controlled, crossover, parallel study, we treated 20 adults who had seasonal allergic rhinitis with once-daily fixed-combination loratadine/pseudoephedrine sulfate to observe its effect on relieving symptoms, primarily nasal congestion. Acoustic rhinometry detected a trend toward improvement in nasal patency, although the difference between pre- and post-treatment measures was not statistically significant. Endoscopic inferior turbinate photography documented that treatment led to statistically significant reductions in the amount of nasal edema and nasal secretions. The results of a quality-of-life questionnaire suggested that treatment alleviated nasal and ocular symptoms of rhinoconjunctivitis. An analysis of subjective visual analog scale scores showed a trend toward improvement in most but not all nasal symptoms. We conclude that once-a-day fixed-combination loratadine/pseudoephedrine is effective in relieving nasal congestion in patients with seasonal allergic rhinitis.
Authors	E A McFadden, A Gungor, B Ng, B Mamikoglu, R Moinuddin, J Corey
Journal	Ear, nose, & throat journal (Ear Nose Throat J) Vol. 79 Issue 4 Pg. 254, 257-8, 260 passim (Apr 2000) ISSN: 0145-5613 [Print] United States
PMID	10786387 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Allergic Agents Drug Combinations Histamine H1 Antagonists Vasoconstrictor Agents Loratadine Ephedrine
Topics	Adult Anti-Allergic Agents (administration & dosage, therapeutic use) Cross-Over Studies Double-Blind Method Drug Administration Schedule Drug Combinations Endoscopy Ephedrine (administration & dosage, therapeutic use) Female Histamine H1 Antagonists (administration & dosage, therapeutic use) Humans Loratadine (administration & dosage, therapeutic use) Male Middle Aged Patient Satisfaction Photography Quality of Life (psychology) Rhinitis, Allergic, Seasonal (drug therapy, psychology) Treatment Outcome Vasoconstrictor Agents (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!