Abstract |
Casein phosphopeptides ( CPP) stabilize amorphous calcium phosphate (ACP) and may be used to localize ACP in dental plaque, maintaining a state of supersaturation with respect to tooth enamel, reducing demineralization and enhancing remineralization. The aim here was to investigate these effects by measuring the effect of CPP-ACP on calcium diffusion in plaque. Using Dibdin's effusion system, calcium diffusion was measured in streptococcal model plaques. This demonstrated that by providing a large number of possible binding sites for calcium, 0.1% CPP-ACP reduces the calcium diffusion coefficient by about 65% at pH 7 and 35% at pH 5. Hence, CPP-ACP binds well to plaque, providing a large calcium reservoir within the plaque and slowing diffusion of free calcium. This is likely to restrict mineral loss during a cariogenic episode and provide a potential source of calcium for subsequent remineralization. Overall, once in place, CPP-ACP will restrict the caries process.
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Authors | R K Rose |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 45
Issue 7
Pg. 569-75
(Jul 2000)
ISSN: 0003-9969 [Print] England |
PMID | 10785520
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Phosphates
- Cariostatic Agents
- Caseins
- Phosphopeptides
- alpha-tricalcium phosphate
- amorphous calcium phosphate
- tetracalcium phosphate
- calcium phosphate, monobasic, anhydrous
- calcium phosphate
- calcium phosphate, dibasic, anhydrous
- Calcium
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Topics |
- Analysis of Variance
- Calcium
(metabolism)
- Calcium Phosphates
(pharmacology, therapeutic use)
- Cariostatic Agents
(pharmacology, therapeutic use)
- Caseins
(pharmacology, therapeutic use)
- Dental Plaque
(drug therapy, metabolism)
- Diffusion
(drug effects)
- Drug Evaluation, Preclinical
- Humans
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Phosphopeptides
(pharmacology, therapeutic use)
- Streptococcal Infections
(drug therapy, metabolism)
- Streptococcus mutans
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