New lanostanoids of Ganoderma tsugae.

Abstract

Three new compounds, (24R, S)-3alpha-acetoxy-24-hydroxy-5alpha-lanosta-8,25-di en-21-oic acid, named tsugaric acid C (1); 3alpha-acetoxy-5alpha-lanosta-8, 24-diene-21-O-beta-D-xyloside, named tsugarioside B (2); and 3alpha-acetoxy-(Z)-24-methyl-5alpha-lanosta-8,23,25-tr ien-21-oic acid ester beta-D-xyloside, named tsugarioside C (3), and a mixture of two known steroids were isolated from the fruit bodies of Ganoderma tsugae. The structures of 1-3 were determined by spectral and chemical methods. The cytotoxic activity of the lanostanoid constituents of this fungus was evaluated against several different cancer cell lines.

• Authors: H J Su, Y F Fann, M I Chung, S J Won, C N Lin
• Journal: Journal of natural products (J Nat Prod) Vol. 63 Issue 4 Pg. 514-6 (Apr 2000) ISSN: 0163-3864 [Print] United States
• PMID: 10785428 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• tsugaric acid
• tsugarioside B
• tsugarioside C
• Lanosterol

Topics

• Drug Screening Assays, Antitumor
• Drugs, Chinese Herbal (chemistry)
• Humans
• Lanosterol (analogs & derivatives, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Oxidation-Reduction
• Reishi
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry, Infrared
• Tumor Cells, Cultured