Abstract |
The objectives of the study were to assess the magnitude of the effect of the leukotriene receptor antagonist, zafirlukast, against cold air-induced bronchoconstriction following the first dose and to assess magnitude and duration after 5 days of dosing. Nineteen patients with asthma were included. In a randomized cross-over design, either zafirlukast 20 mg or 80 mg b.d. or placebo were given over 5 days. Challenges were performed 3 h post first dose and 3, 8, 12 and 24 h post last dose. The authors assessed the provocative ventilation rate necessary to achieve a 10% (PV10) and 20% (PV20) fall in forced expiratory volume in one second. The median PV20 3 h post first dose was 69.1 L x min-1 for zafirlukast 80 mg compared to 40 L x min-1 for placebo (p=0.004). The corresponding median value for zafirlukast 20 mg was 59.9 L x min-1 (p=0.06). At steady state the differences in PV20, between zafirlukast 80 mg and placebo were significant at 8 h and 12 h post last dose. The corresponding difference for zafirlukast 20 mg was statistically significant at 8 h post last dose. The analysis of PV10 yielded compatible results. There was no significant protection 24 h after last dose. This study has demonstrated that zafirlukast offers significant protection against cold air-induced bronchoconstriction in asthma. The degree and duration of protection were dose-dependent. However, there was a large interindividual variability for the protective effect of this leukotriene receptor antagonist.
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Authors | K Richter, R A Jörres, H Magnussen |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 15
Issue 4
Pg. 693-9
(Apr 2000)
ISSN: 0903-1936 [Print] England |
PMID | 10780761
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- Leukotriene Antagonists
- Phenylcarbamates
- Sulfonamides
- Tosyl Compounds
- zafirlukast
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Topics |
- Administration, Inhalation
- Adult
- Air
- Analysis of Variance
- Asthma
(diagnosis, drug therapy, physiopathology)
- Bronchial Provocation Tests
- Bronchoconstriction
(drug effects)
- Cold Temperature
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Indoles
- Leukotriene Antagonists
(administration & dosage)
- Male
- Middle Aged
- Phenylcarbamates
- Probability
- Respiratory Function Tests
- Sulfonamides
- Tosyl Compounds
(administration & dosage)
- Treatment Outcome
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