Abstract | BACKGROUND: METHODS: Fifteen-day-old Fischer rats were treated orally with single or combined applications of CsA, nifedipine, and/or diltiazem for 40 days; and induced gingival overgrowth, rat growth, and blood drug levels were compared among the different experimental groups. The experiment consisted of 6 groups: one control group (group A) and 5 test groups treated with CsA (group B), nifedipine (group C), and diltiazem (group D), as well as those concurrently treated with CsA and nifedipine (group E), and CsA and diltiazem (group F). Gingival overgrowth was determined by measuring the depth of the gingival sulcus. RESULTS: The mandibular buccal gingival sulcus depth of group A was 365 +/- 41.2 microm. Among the test groups, the most remarkable gingival overgrowth was seen in group E (1,020 +/- 63.3 microm), followed by group F (895 +/- 43.8 microm), group B (870 +/- 48.3 microm), group C (525 +/- 116 microm), and then group D (505 +/- 83.2 microm). Rat body weight gain was reduced significantly by oral CsA treatment. Neither nifedipine nor diltiazem suppressed rat growth when used independently; however, rat growth reduced by CsA was further suppressed by a combined use of diltiazem, but not nifedipine. CsA blood levels were reduced by concurrent oral treatment with nifedipine or diltiazem along with the blood levels of those calcium channel blockers when treatment was in combination with CsA. CONCLUSIONS:
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Authors | I Morisaki, N Fukui, Y Fujimori, J Murakami, H Daikoku, A Amano |
Journal | Journal of periodontology
(J Periodontol)
Vol. 71
Issue 3
Pg. 438-43
(Mar 2000)
ISSN: 0022-3492 [Print] United States |
PMID | 10776932
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Blockers
- Drug Combinations
- Immunosuppressive Agents
- Cyclosporine
- Diltiazem
- Nifedipine
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Topics |
- Administration, Oral
- Analysis of Variance
- Animals
- Body Weight
(drug effects)
- Calcium Channel Blockers
(administration & dosage, adverse effects, blood)
- Cyclosporine
(administration & dosage, adverse effects, blood)
- Diltiazem
(administration & dosage, adverse effects, blood)
- Drug Combinations
- Drug Interactions
- Gingiva
(drug effects)
- Gingival Overgrowth
(chemically induced, classification)
- Growth
(drug effects)
- Immunosuppressive Agents
(administration & dosage, adverse effects, blood)
- Male
- Nifedipine
(administration & dosage, adverse effects, blood)
- Rats
- Rats, Inbred F344
- Single-Blind Method
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