Role of nuclear medicine in the evaluation of the solitary pulmonary nodule.

Abstract

Tomographic imaging with either F-18 fluoro deoxyglucose (FDG) (a nonmetabolizable glucose analog that reflects tumor increased glucose metabolism) or technetium Tc-99m Depreotide (a synthetic peptide that binds with high affinity to cell surface receptors with increased expression on certain tumor cells) provides improved sensitivity and specificity in the differential diagnosis of solitary pulmonary nodules (SPN) compared with noninvasive and some invasive procedures. F-18 FDG requires instrumentation capable of coincident imaging whereas Tc-99m Depreotide can be imaged on standard gamma cameras equipped to perform single photon emission computed tomography (SPECT) imaging. Either technique performs better than CT alone, and both are cost effective on the basis of reducing unnecessary biopsies and thoracotomies in patients with negative studies indicating that the SPN is nonmalignant.

• Authors: S J Goldsmith, L Kostakoglu
• Journal: Seminars in ultrasound, CT, and MR (Semin Ultrasound CT MR) Vol. 21 Issue 2 Pg. 129-38 (Apr 2000) ISSN: 0887-2171 [Print] United States
• PMID: 10776885 (Publication Type: Case Reports, Comparative Study, Journal Article, Review)

Chemical References

• Contrast Media
• Intercellular Signaling Peptides and Proteins
• NeoTect
• Peptides
• Radiopharmaceuticals
• Receptors, Somatostatin
• Fluorodeoxyglucose F18
• Technetium

Topics

• Aged
• Contrast Media
• Diagnosis, Differential
• Fluorodeoxyglucose F18
• Humans
• Intercellular Signaling Peptides and Proteins
• Lung Neoplasms (diagnostic imaging)
• Male
• Middle Aged
• Peptides
• Radiopharmaceuticals
• Receptors, Somatostatin (drug effects)
• Sensitivity and Specificity
• Solitary Pulmonary Nodule (diagnostic imaging)
• Technetium
• Tomography, Emission-Computed
• Tomography, Emission-Computed, Single-Photon