Abstract | OBJECTIVE: To assess the production of prostaglandin E(2), an important chemical mediator in diarrhea induced by laxative administration, a prostaglandin E-main urinary metabolite (7alpha-hydroxy-5,11-diketotetranor-prosta-1,16-dioic acid, PGE-MUM) was measured in healthy volunteers and compared with the values of patients with ulcerative colitis. METHODS: RESULTS: Administration of laxatives induced a significant increase in PGE-MUM in healthy volunteers. A significant elevation was also found in the active as compared with the remission phase of ulcerative colitis. The PGE-MUM levels were significantly correlated with our modified Talstad scores, clinical disease activity indices in ulcerative colitis. It was confirmed by time course studies of individual patients that changes in PGE-MUM correlated well with colitis activity. CONCLUSION:
Laxative administration induces production of prostaglandin E(2) as one of the chemical mediators, although its production grade is relatively low as compared with ulcerative colitis in the active phase.
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Authors | M Fujiwara, I Okayasu, M Oritsu, J Komatsu, M Yoshitsugu, Y Katoh, T Bandoh, H Toyoshima, Y Kase, K Sugihara, J Kanno, Y Hayashi |
Journal | Digestion
(Digestion)
Vol. 61
Issue 3
Pg. 201-6
( 2000)
ISSN: 0012-2823 [Print] Switzerland |
PMID | 10773726
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2000 S. Karger AG, Basel |
Chemical References |
- Anthraquinones
- Cathartics
- Organometallic Compounds
- Prostanoic Acids
- Sennosides
- 11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid
- Citric Acid
- Senna Extract
- magnesium citrate
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Topics |
- Aged
- Anthraquinones
(administration & dosage)
- Cathartics
(administration & dosage)
- Citric Acid
(administration & dosage)
- Colitis, Ulcerative
(urine)
- Female
- Humans
- Male
- Middle Aged
- Organometallic Compounds
(administration & dosage)
- Prostanoic Acids
(urine)
- Senna Extract
- Sennosides
- Statistics, Nonparametric
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