Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.

Abstract

Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study. To examine whether phenolphthalein carcinogenic potential can be detected in male and female transgenic (Tg) mice carrying the human c-Ha-ras gene (rasH2 mice) and their wild-type littermates (non-Tg mice), a diet containing 3000, 6000 or 12000 ppm was given for 6 months. Unequivocal induction of neoplastic lesions was not apparent, suggesting that rasH2 mice are resistant to the induction of malignant lymphomas by the treatment of phenolphthalein.

• Authors: T Koujitani, K Yasuhara, T Usui, T Nomura, H Onodera, H Takagi, M Hirose, K Mitsumori
• Journal: Cancer letters (Cancer Lett) Vol. 152 Issue 2 Pg. 211-6 (May 01 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10773414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• MAS1 protein, human
• Proto-Oncogene Mas
• Phenolphthalein

Topics

• Adenoma, Liver Cell (chemically induced)
• Animals
• Body Weight (drug effects)
• Carcinogenicity Tests (methods)
• Carcinogens (toxicity)
• Female
• Genes, ras (genetics)
• Hemangiosarcoma (chemically induced)
• Humans
• Lung Neoplasms (chemically induced)
• Lymphoma (chemically induced)
• Male
• Mice
• Mice, Transgenic
• Phenolphthalein (toxicity)
• Proto-Oncogene Mas
• Splenic Neoplasms (chemically induced)
• Thymus Neoplasms (chemically induced)
• Time Factors