Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs.

Abstract

The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.

• Authors: E R Kern, J Palmer, G Szczech, G Painter, K Y Hostetler
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) 2000 Jan-Feb Vol. 19 Issue 1-2 Pg. 501-13 ISSN: 1525-7770 [Print] United States
• PMID: 10772730 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• penciclovir
• Guanine
• acyclovir monophosphate
• Acyclovir

Topics

• Acyclovir (administration & dosage, analogs & derivatives, therapeutic use)
• Administration, Topical
• Animals
• Antiviral Agents (administration & dosage, therapeutic use)
• Female
• Guanine
• Guinea Pigs
• Herpes Genitalis (drug therapy, pathology)
• Herpes Labialis (drug therapy, pathology)
• Herpesvirus 1, Human (drug effects)
• Herpesvirus 2, Human (drug effects)
• Mice
• Mice, Hairless