HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-tumor effect of N-beta-alanyl-5-S-glutathionyldihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect.

AbstractPURPOSE:
We examined the anti-tumor effect of 5-S-GAD, a novel potent inhibitor of protein tyrosine kinases, isolated from the flesh fly in order to investigate the potential use of this compound as an anti-tumor agent.
METHODS:
In vitro growth inhibition was evaluated using the alamarBlue assay kit. In vivo anti-tumor activity was evaluated by i.p. treatment of 5-S-GAD against xenografted melanoma (LOX-IMV1) and breast carcinoma (MDA-MB-435S) in nude mice.
RESULTS:
Of 38 human cancer cell lines examined, this compound showed significant cytotoxicity toward two estrogen-negative breast carcinomas (MDA-MB-231 and MDA-MB-435S) and one malignant melanoma (LOX-IMV1) in vitro, indicating that it exhibits selective cytotoxicity to certain tumor cell lines. In accordance with its in vitro anti-tumor effect, 5-S-GAD was shown to significantly repress the growth of sensitive tumor cells in nude mice.
CONCLUSION:
These results indicate that 5-S-GAD is potentially useful to treat certain human cancer.
AuthorsN Akiyama, M Hijikata, A Kobayashi, T Yamori, T Tsuruo, S Natori
JournalAnticancer research (Anticancer Res) 2000 Jan-Feb Vol. 20 Issue 1A Pg. 357-62 ISSN: 0250-7005 [Print] Greece
PMID10769680 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Benzoquinones
  • Enzyme Inhibitors
  • Lactams, Macrocyclic
  • N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine
  • Neoplasm Proteins
  • Quinones
  • Rifabutin
  • Dihydroxyphenylalanine
  • herbimycin
  • Protein-Tyrosine Kinases
  • Glutathione
Topics
  • Animals
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Benzoquinones
  • Breast Neoplasms (pathology)
  • Dihydroxyphenylalanine (analogs & derivatives, pharmacology, therapeutic use)
  • Diptera (chemistry)
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors (pharmacology, therapeutic use)
  • Female
  • Glutathione (analogs & derivatives, pharmacology, therapeutic use)
  • Humans
  • Lactams, Macrocyclic
  • Mammary Neoplasms, Experimental (drug therapy)
  • Melanoma (pathology)
  • Melanoma, Experimental (drug therapy)
  • Mice
  • Mice, Nude
  • Molecular Structure
  • Neoplasm Proteins (antagonists & inhibitors)
  • Neoplasm Transplantation
  • Protein-Tyrosine Kinases (antagonists & inhibitors)
  • Quinones (pharmacology)
  • Rifabutin (analogs & derivatives)
  • Transplantation, Heterologous
  • Tumor Cells, Cultured (drug effects, transplantation)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: