Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest.

Abstract

There is evidence that habitual consumption of green tea by Japanese men is correlated with a reduction in cancers, including prostate; soybean isoflavones are also associated with increased protection. The present study compared the anti-proliferative effect of black tea (Camellia sinensis) polyphenol, thearubigin (TR), alone or combined with the isoflavone genistein, on human prostate (PC-3) carcinoma cells. TR administered alone did not result in any alteration of cell growth. When combined with genistein, however, TR significantly inhibited cell growth and induced a G2/M phase cell cycle arrest in a dose dependent manner. These findings indicate the potential use of combined phytochemicals to provide protection against prostate cancer.

• Authors: K Sakamoto
• Journal: Cancer letters (Cancer Lett) Vol. 151 Issue 1 Pg. 103-9 (Apr 03 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10766429 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antioxidants
• DNA, Neoplasm
• Phenols
• Polyphenols
• Tea
• thearubigin
• Catechin
• Genistein

Topics

• Anticarcinogenic Agents
• Antioxidants (toxicity)
• Catechin (analogs & derivatives, toxicity)
• Cell Cycle (drug effects)
• Cell Division (drug effects)
• DNA, Neoplasm (drug effects, metabolism)
• Drug Synergism
• Genistein (toxicity)
• Humans
• Japan
• Male
• Phenols (toxicity)
• Phytotherapy
• Polyphenols
• Prostatic Neoplasms
• Tea (therapeutic use)
• Tumor Cells, Cultured