Abstract | PURPOSE: METHODS: Immunofluorescent staining and Western blotting were performed to grade the level of expression of the epidermal growth factor receptor ErbB2, and ErbB3 in conjunctival epithelial impression cytologies taken from both eyes of seven normal subjects and 22 patients with keratoconjunctivitis sicca. RESULTS: CONCLUSION: The expression of the type 1 growth factor receptors is significantly greater in the conjunctival epithelium of eyes with keratoconjunctivitis sicca than normal eyes. The increased expression of these receptors was positively correlated with ocular surface dye staining. The increased expression of these receptors may contribute to the abnormal growth and differentiation of the conjunctival epithelium that occurs in keratoconjunctivitis sicca.
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Authors | Z Liu, M Carvajal, C A Carothers Carraway, K L Carraway, S C Pflugfelder |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 129
Issue 4
Pg. 472-80
(Apr 2000)
ISSN: 0002-9394 [Print] United States |
PMID | 10764856
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Monoclonal
- Receptor, ErbB-2
- Receptor, ErbB-3
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Topics |
- Adult
- Aged
- Antibodies, Monoclonal
- Blotting, Western
- Conjunctiva
(metabolism, pathology)
- Epithelium
(metabolism, pathology)
- Female
- Fluorescent Antibody Technique, Indirect
- Humans
- Keratoconjunctivitis Sicca
(metabolism, pathology)
- Middle Aged
- Receptor, ErbB-2
(biosynthesis)
- Receptor, ErbB-3
(biosynthesis)
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