[The effect of GABA-positive agents on the formation of morphine dependence and on the manifestations of a withdrawal syndrome].

Abstract

Experiments on mice showed that the GABA-positive preparations (THIP, baclofen, fenibut, valproate sodium) intraperitoneally injected in the course of the morphine addiction development (double daily subcutaneous injections at a dose increasing from 10 to 100 mg/kg over a period of 8 days) and, to a greater extent, upon cessation of the morphine injections, partly reduce manifestations of the naloxone-enhanced (0.1 mg/kg, s.c.) daily abstinence, as evaluated by the hopping activity and pair interaction tests.

• Authors: I V Belozertseva, B V Andreev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2000 Jan-Feb Vol. 63 Issue 1 Pg. 19-23 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie GAMK-pozitivnykh sredstv na formirovanie zavisimosti ot morfina i proiavleniia sindroma otmeny.
• PMID: 10763104 (Publication Type: English Abstract, Journal Article)

Chemical References

• GABA Agonists
• GABA Antagonists
• Narcotic Antagonists
• Narcotics
• Naloxone
• Morphine

Topics

• Animals
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• GABA Agonists (therapeutic use)
• GABA Antagonists (therapeutic use)
• Male
• Mice
• Morphine (adverse effects)
• Morphine Dependence (drug therapy, etiology)
• Naloxone (therapeutic use)
• Narcotic Antagonists (therapeutic use)
• Narcotics (adverse effects)
• Substance Withdrawal Syndrome (drug therapy, etiology)
• Time Factors