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Effects of serotoninergic drugs on tremor induced by physostigmine in rats.

Abstract
We investigated the effects of various serotoninergic drugs and serotonin (5-HT) depletion on physostigmine-induced visible tremor in rats. Physostigmine (0.25-1.5 mg/kg) caused dose-dependent tremor, initiated at 3-5 min (latency decreases as dose increases) and lasted for 30-35 min. Serotonin agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (2.5 mg/kg) and buspirone (5 mg/kg) augmented the tremor response caused by physostigmine. The 5-HT(1)/5-HT(2) receptor antagonist, metergoline (1 mg/kg), and 5-HT(2) blocker, cyproheptadine (10 mg/kg) significantly decreased the duration (40%) as well as intensity (45-50%) of physostigmine-tremor. The 5-HT(2a)/5-HT(2c) antagonist ritanserin (5 mg/kg) significantly reduced the duration (60%) without affecting the intensity of the tremor. In 5-HT depleted rats (p-chlorophenylalanine; 300 mg/kg, for 3 days), physostigmine failed to produce tremor. Interestingly, in these animals, administration of a non-specific 5-HT agonist, 5-methoxy-N,N-dimethyl tryptamine, caused high intensity tremor. These results suggest that presence of 5-HT at the pre-synaptic terminals is needed for the tremor response by physostigmine and the response is greatly mediated via post-synaptic 5-HT receptors. The overall data indicated a direct involvement of central 5-HT system in the cholinergic tremor induced by physostigmine.
AuthorsS Sarkar, B Thomas, D Muralikrishnan, K P Mohanakumar
JournalBehavioural brain research (Behav Brain Res) Vol. 109 Issue 2 Pg. 187-93 (May 2000) ISSN: 0166-4328 [Print] Netherlands
PMID10762688 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholinesterase Inhibitors
  • Receptors, Serotonin
  • Serotonin Agents
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Tetrahydronaphthalenes
  • Ritanserin
  • Metergoline
  • Cyproheptadine
  • Serotonin
  • Physostigmine
  • tetralin
  • Buspirone
  • N,N-Dimethyltryptamine
Topics
  • Animals
  • Buspirone (pharmacology)
  • Cholinesterase Inhibitors (adverse effects)
  • Cyproheptadine (pharmacology)
  • Metergoline (pharmacology)
  • N,N-Dimethyltryptamine (pharmacology)
  • Physostigmine (adverse effects)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin (drug effects, metabolism)
  • Ritanserin (pharmacology)
  • Serotonin (metabolism, physiology)
  • Serotonin Agents (pharmacology)
  • Serotonin Antagonists (pharmacology)
  • Serotonin Receptor Agonists (pharmacology)
  • Tetrahydronaphthalenes (pharmacology)
  • Tremor (chemically induced)

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