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Expression of the interferon-inducible chemokines MuMig and Crg-2 following vaccinia virus infection in vivo.

Abstract
MuMig (monokine induced by gamma interferon) and Crg-2 (cytokine responsive gene) are chemokines of the CXC subfamily. They share activity as T and NK cell chemoattractants. Crg-2 has been shown to be inducible by IFN, TNF, IL-1 and LPS, whereas the expression of MuMig is thought to be strictly dependent on IFN-gamma. In the present study, the kinetics of expression of the genes for MuMig and Crg-2 were analysed by northern blot analysis in organs of normal mice and in groups of gene knockout mice deficient in IFN-gamma (IFN-gamma-/-) or receptors for IFN-alpha/beta and IFN-gamma (double R-/-; DR-/-) after vaccinia virus infection. MuMig mRNA was not expressed in IFN-gamma-/- mice in all organs examined, whereas Crg-2 mRNA levels were marginally reduced. In contrast, MuMig and Crg-2 mRNA transcripts were completely abolished in the DR-/- mice.
AuthorsS Mahalingam, G Karupiah
JournalImmunology and cell biology (Immunol Cell Biol) Vol. 78 Issue 2 Pg. 156-60 (Apr 2000) ISSN: 0818-9641 [Print] United States
PMID10762416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines, CXC
  • Cxcl10 protein, mouse
  • Cxcl9 protein, mouse
  • Monokines
  • RNA, Messenger
  • Receptors, Interferon
  • Interferon-gamma
Topics
  • Animals
  • Blotting, Northern
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines, CXC (metabolism)
  • Female
  • Interferon-gamma (deficiency)
  • Kinetics
  • Liver (metabolism)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Monokines (metabolism)
  • Ovary (metabolism)
  • RNA, Messenger (analysis)
  • Receptors, Interferon (deficiency)
  • Spleen (metabolism)
  • Uterus (metabolism)
  • Vaccinia (metabolism, virology)
  • Vaccinia virus

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