Sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphynyl(IX)-6,7-dia spartic acid (ATX-S10).

Abstract

The sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphyn yl(IX)-6,7-diaspartic acid (ATX-S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 microM ATX-S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX-S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.

• Authors: N Yumita, R Nishigaki, I Sakata, S Nakajima, S Umemura
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 91 Issue 2 Pg. 255-60 (Feb 2000) ISSN: 0910-5050 [Print] Japan
• PMID: 10761714 (Publication Type: Journal Article)

Chemical References

• ATX-S10
• Antineoplastic Agents
• Photosensitizing Agents
• Porphyrins
• Hydroxyl Radical
• Histidine

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Histidine (pharmacology)
• Hydroxyl Radical
• Male
• Mice
• Mice, Inbred ICR
• Neoplasms, Experimental (therapy)
• Photosensitizing Agents (pharmacology)
• Porphyrins (pharmacology)
• Ultrasonic Therapy