Abstract |
The sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphyn yl(IX)-6,7-diaspartic acid (ATX-S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 microM ATX-S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX-S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.
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Authors | N Yumita, R Nishigaki, I Sakata, S Nakajima, S Umemura |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 91
Issue 2
Pg. 255-60
(Feb 2000)
ISSN: 0910-5050 [Print] Japan |
PMID | 10761714
(Publication Type: Journal Article)
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Chemical References |
- ATX-S10
- Antineoplastic Agents
- Photosensitizing Agents
- Porphyrins
- Hydroxyl Radical
- Histidine
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Histidine
(pharmacology)
- Hydroxyl Radical
- Male
- Mice
- Mice, Inbred ICR
- Neoplasms, Experimental
(therapy)
- Photosensitizing Agents
(pharmacology)
- Porphyrins
(pharmacology)
- Ultrasonic Therapy
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