[Hepatoprotective action of phosphogliv in surgery of patients with chronic calculous cholecystitis].

Abstract

32 patients with chronic calculous cholecystitis were treated by a new preparation. Phosphogliv (on the base of polyunsaturated phospholipids)--5 days before planned surgery and 5 days after. The increase of alanine and asparagine aminotransferases activities and of bilirubin concentration (2-2.5 fold) was observed in all the patients, cirespective of the drug treatment. However, the essential difference between treated and untreated patients was revealed in the course of post-operative period. In the control group asparagine aminotransferase activity and bilirubin level remained high, and alanine aminotransferases activity even more increased. In contrast, both two aminotransferases activities and bilirubin level fell substantially in Phosphogliv group, that may show more active liver regeneration after surgery. Besides, in this group operation did not result even in short-time changes of plasma protein fractions ratios--opposite to control. It may testify on some protective action of Phosphogliv on liver protein-synthesis system. The observed action of new phospholipid preparation Phosphogliv, together with the absence of side effects, allows to recommend it as an adjuvant in the surgery of patients with chronic calculous cholecystitis. Besides, the above results broaden usage field of polyunsaturated phosphatidylcholine as cell membranes repair agent: it appears to be effective not only for liver diseases treatment, but also for soonest overcome of post-surgery liver changes.

• Authors: V F Uchaĭkin, E I Gal'perin, V A Kniazhev, K V Dokuchaev, T I Torkhovskaia, O B Kovalev, O M Ipatova, M K Guseva, E G Tikhonova, A I Archakov
• Journal: Khirurgiia (Khirurgiia (Mosk)) Issue 3 Pg. 14-7 ( 2000) ISSN: 0023-1207 [Print] Russia (Federation)
• Vernacular Title: Gepatoprotektornoe deĭstvie fosfogliva u bol'nykh, operirovannykh po povodu khronicheskogo kal'kuleznogo kholetsistita.
• PMID: 10761375 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Phosphatidylcholines
• Transaminases
• Bilirubin

Topics

• Bilirubin (blood)
• Cholecystectomy
• Cholelithiasis (blood, complications, surgery)
• Cholestasis (blood, etiology, prevention & control)
• Chronic Disease
• Humans
• Liver (drug effects, metabolism)
• Liver Regeneration (drug effects)
• Middle Aged
• Phosphatidylcholines (therapeutic use)
• Postoperative Care
• Preoperative Care
• Transaminases (blood)
• Treatment Outcome