[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators].

Abstract

A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.

• Authors: V B Prozorovskiĭ, L V Pavlova, I M Suslova, A V Sazonova, A V Kokushkina
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1999 Nov-Dec Vol. 45 Issue 6 Pg. 525-9 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Zashchita mysheĭ ingibitorami kholinésterazy iz klassa karbamatov ot otravleniia arminom i zavisimost' ot nekotorykh fiziko-khimicheskikh pokazateleĭ.
• PMID: 10761219 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbamates
• Cholinesterase Inhibitors
• Pyridines
• aminostigmine
• Armin
• Pyridostigmine Bromide

Topics

• Animals
• Armin (toxicity)
• Carbamates (chemistry, pharmacology)
• Cholinesterase Inhibitors (chemistry, pharmacology, toxicity)
• Humans
• Male
• Mice
• Poisoning (prevention & control)
• Pyridines
• Pyridostigmine Bromide (analogs & derivatives)
• Structure-Activity Relationship