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[The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450].

Abstract
gamma-L-Glutamyl-histamine (gamma-GluHA) was synthesized at Department of the chemistry and technology of fine organic compounds M. V. Lomonosov Moscow state academy of fine chemical technology. It was investigated the influence of gamma-L-glutamyl-histamine on the severity of experimental anaphylactic reaction, hormonal content in blood plasma and liver cytochrome P-450. The induction of liver cytochrome P-450, the elevation of hormonal content (thyroxine and glucocorticoids) in blood plasma and decrease of the severity of experimental anaphylactic reaction are observed.
AuthorsV E Nebol'sin, V V Krzhechkovskaia, G A Zheltukhina, R P Evstigneeva, V L Kovaleva
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 1999 Nov-Dec Vol. 45 Issue 6 Pg. 482-8 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleVliianie gamma-L-glutamilgistamina na izmenenie tiazhesti proiavleniĭ éksperimental;noĭ anafilakticheskoĭ reaktsii, gormonal'nogo statusa i sistemy tsitokhroma p-450 pecheni.
PMID10761213 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Hormones
  • gamma-glutamylhistamine
  • Histamine
  • Cytochrome P-450 Enzyme System
Topics
  • Anaphylaxis (drug therapy, metabolism)
  • Animals
  • Cytochrome P-450 Enzyme System (metabolism)
  • Guinea Pigs
  • Histamine (analogs & derivatives, chemistry, pharmacology, therapeutic use)
  • Hormones (blood)
  • Liver (drug effects, enzymology)
  • Mice
  • Mice, Inbred BALB C

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