Abstract | OBJECTIVE: To measure the blood apolipoprotein A-1 and apolipoprotein B in the fetal circulation in normal pregnancy and in pregnancy with evidence of vascular disease in the fetal umbilical placental circulation defined in the antenatal period by Doppler ultrasound study. DESIGN: An observational study to compare fetal plasma apolipoprotein levels in normal and complicated pregnancy. SETTING: A university hospital tertiary referral obstetric unit. SAMPLES: Umbilical vein blood was collected at delivery from 22 normal fetuses delivered by elective caesarean section for non fetal reasons and 30 fetuses with evidence of umbilical placental vascular disease identified antenatally by Doppler ultrasound study. METHODS: MAIN OUTCOME MEASURES: RESULTS: There was a significantly lower level of fetal plasma apolipoprotein A-1 in placental insufficiency [ placental insufficiency vs normal pregnancy, median 0.30 g/L (interquartile range 0.24, 0.39 g/L) vs 0.35 g/L (0.31, 0.42 g/L), P = 0.045]. In contrast, the levels of fetal plasma apolipoprotein B in placental insufficiency [0.20 g/L (0.17, 0.26 g/L)] were significantly increased compared with normal pregnancy [0.16 g/L (0. 14, 0.20 g/L), P = 0.03]. The ratio of fetal plasma apolipoprotein B to A-1 was also substantially higher in placental insufficiency [0.68 (0.55, 0.83)] than in normal pregnancy [0.45 (0.36, 0.60), P = 0.0003]. CONCLUSIONS:
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Authors | J Wang, B Trudinger |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 107
Issue 4
Pg. 508-13
(Apr 2000)
ISSN: 1470-0328 [Print] England |
PMID | 10759270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apolipoproteins A
- Apolipoproteins B
- Biomarkers
|
Topics |
- Adult
- Apolipoproteins A
(blood)
- Apolipoproteins B
(blood)
- Biomarkers
(blood)
- Female
- Fetal Blood
(chemistry)
- Humans
- Placental Insufficiency
(blood)
- Pregnancy
- Pregnancy Complications
- Pregnancy Trimester, Third
(blood)
- Ultrasonography, Prenatal
- Umbilical Cord
(diagnostic imaging)
- Vascular Diseases
(blood)
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