Granisetron/dexamethasone combination for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.

Abstract	Dexamethasone decreases chemotherapy-induced emesis when added to an antiemetic regimen. This study was undertaken to evaluate the efficacy of granisetron/dexamethasone combination for preventing postoperative nausea and vomiting (PONV) after lapIaroscopic cholecystectomy (LC). In a prospective, randomized, double-blind manner, 120 patients (83 females), aged 25-65 years, were assigned to receive granisetron 40 microg kg-1 alone or granisetron 40 microg kg-1 plus dexamethasone 8 mg (n=60 of each) intravenously immediately before the induction of anaesthesia. A standardized general anaesthetic procedure and postoperative analgesia were used. A complete response, defined as no PONV and no need for another rescue antiemetic, during 0-3 h after anaesthesia was 83% with granisetron and 98% with granisetron plus dexamethasone, respectively (P=0.008); the corresponding incidence during 3-24 h after anaesthesia was 83% and 98% (P=0.008). No clinically important adverse events were observed in any of the group. In conclusion, prophylactic therapy with granisetron/dexamethasone combination is more effective than granisetron alone for the prevention of PONV after LC.
Authors	Y Fujii, Y Saitoh, H Tanaka, H Toyooka
Journal	European journal of anaesthesiology (Eur J Anaesthesiol) Vol. 17 Issue 1 Pg. 64-8 (Jan 2000) ISSN: 0265-0215 [Print] England
PMID	10758447 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Retracted Publication)
Chemical References	Antiemetics Drug Combinations Dexamethasone Granisetron
Topics	Adult Aged Analgesia Anesthesia, General Antiemetics (administration & dosage, adverse effects, therapeutic use) Cholecystectomy, Laparoscopic (adverse effects) Dexamethasone (administration & dosage, adverse effects, therapeutic use) Double-Blind Method Drug Combinations Female Follow-Up Studies Granisetron (administration & dosage, adverse effects, therapeutic use) Humans Incidence Injections, Intravenous Male Middle Aged Postoperative Nausea and Vomiting (prevention & control) Premedication Prospective Studies

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