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Sin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome.

Abstract
Serum samples from 22 hantavirus pulmonary syndrome (HPS) patients were tested for Sin Nombre virus (SNV)-reactive antibodies. In the acute phase of HPS, 100% and 67% of the samples tested positive for SNV-specific immunoglobulin (Ig) M and IgA, respectively. Among the virus-specific IgG antibodies, the most prevalent were IgG3 (in 97% of samples), followed by IgG1 (70%), IgG2 (30%), and IgG4 (3%).
AuthorsP Bostik, J Winter, T G Ksiazek, P E Rollin, F Villinger, S R Zaki, C J Peters, A A Ansari
JournalEmerging infectious diseases (Emerg Infect Dis) 2000 Mar-Apr Vol. 6 Issue 2 Pg. 184-7 ISSN: 1080-6040 [Print] United States
PMID10756154 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Antigens, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin Isotypes
  • Immunoglobulin M
Topics
  • Acute Disease
  • Antibodies, Viral (blood)
  • Antigens, Viral
  • Chronic Disease
  • Orthohantavirus (immunology)
  • Hantavirus Pulmonary Syndrome (immunology)
  • Humans
  • Immunoglobulin A (blood)
  • Immunoglobulin G (blood, classification)
  • Immunoglobulin Isotypes (blood)
  • Immunoglobulin M (blood)
  • Prognosis

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